Hiroaki Miyajima Selected Research

Familial apoceruloplasmin deficiency

9/2018	Aceruloplasminemia with Abnormal Compound Heterozygous Mutations Developed Neurological Dysfunction during Phlebotomy Therapy.
1/2017	The Resection of Thyroid Cancer Was Associated with the Resolution of Hyporesponsiveness to an Erythropoiesis-stimulating Agent in a Hemodialysis Patient with Aceruloplasminemia.
6/2015	Copper Accumulates in Hemosiderins in Livers of Patients with Iron Overload Syndromes.
11/2014	Case of presymptomatic aceruloplasminemia treated with deferasirox.
9/2012	Clinicopathological study of Japanese patients with genetic iron overload syndromes.
11/2010	Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders.
10/2010	Predominant ataxia, low ceruloplasmin, and absent K-F rings: hypoceruloplasminemia or Wilson's disease.
1/2010	Central diabetes insipidus and hypothalamic hypothyroidism associated with aceruloplasminemia.
4/2008	Aceruloplasminemia: a novel mutation in a family with marked phenotypic variability.
12/2007	Cys-881 is essential for the trafficking and secretion of truncated mutant ceruloplasmin in aceruloplasminemia.

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Hiroaki Miyajima Research Topics

Disease

11	Iron Overload 06/2015 - 12/2002
8	Neoplasms (Cancer) 09/2020 - 09/2003
7	Hemochromatosis (Bronze Diabetes) 06/2015 - 10/2002
5	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2014 - 01/2002
4	Infections 01/2020 - 08/2014
4	Chronic Renal Insufficiency 01/2019 - 04/2015
4	Colorectal Neoplasms (Colorectal Cancer) 02/2018 - 07/2012
4	Cerebellar Ataxia (Dysmetria) 12/2014 - 10/2004
4	Ataxia (Dyssynergia) 11/2010 - 11/2002
4	Dementia (Dementias) 01/2010 - 11/2002
3	Parkinson Disease (Parkinson's Disease) 09/2020 - 01/2007
3	Stomach Neoplasms (Stomach Cancer) 08/2020 - 01/2012
3	Dyskinesias (Dyskinesia) 01/2013 - 11/2002
3	Atherosclerosis 01/2011 - 09/2010
3	Hypercholesterolemia 01/2011 - 09/2010
3	Mitochondrial Diseases (Mitochondrial Disease) 03/2003 - 03/2002
2	Reperfusion Injury 01/2022 - 09/2006
2	Heart Failure 10/2021 - 01/2017
2	Gastroesophageal Reflux (GERD) 07/2021 - 01/2018
2	Muscular Diseases (Myopathy) 01/2021 - 12/2010
2	Esophageal Squamous Cell Carcinoma 11/2020 - 10/2018
2	Adenocarcinoma 09/2020 - 01/2018
2	Diplopia (Double Vision) 05/2020 - 11/2010
2	Ulcerative Colitis 04/2020 - 12/2018
2	Hypertension (High Blood Pressure) 01/2020 - 05/2016
2	Acute Kidney Injury (Acute Renal Failure) 01/2020 - 01/2020
2	Diabetes Mellitus 09/2018 - 01/2010
2	Fibrosis (Cirrhosis) 06/2018 - 09/2012
2	Turcot syndrome 02/2018 - 01/2016
2	Body Weight (Weight, Body) 01/2017 - 09/2010
2	Colitis 01/2017 - 07/2014
2	Neurologic Manifestations (Neurological Manifestations) 11/2014 - 04/2008
2	Atrophy 12/2013 - 07/2003
2	Inborn Genetic Diseases (Disease, Hereditary) 11/2010 - 10/2002
2	Hepatolenticular Degeneration (Wilson's Disease) 10/2010 - 10/2002
2	Gaucher Disease (Gaucher's Disease) 09/2010 - 01/2007
2	Parkinsonian Disorders (Parkinsonism) 09/2010 - 01/2007
2	Congenital Abnormalities (Deformity) 12/2003 - 12/2002
1	Acute Lung Injury 01/2022
1	Ventricular Fibrillation 10/2021
1	Carcinoid Tumor (Carcinoid) 07/2021
1	Renal Insufficiency (Renal Failure) 01/2021
1	Muscle Weakness 01/2021
1	Esophageal Neoplasms (Esophageal Cancer) 11/2020
1	Chromosomal Instability (Chromosome Stability) 09/2020
1	Paralysis (Palsy) 05/2020
1	Foreign-Body Granuloma (Granuloma, Foreign Body) 05/2020
1	Paresthesia (Dysesthesia) 05/2020

Drug/Important Bio-Agent (IBA)

21	Familial apoceruloplasmin deficiencyIBA 09/2018 - 01/2002
18	IronIBA 06/2015 - 01/2002
12	Ceruloplasmin (Ferroxidase)IBA 11/2014 - 01/2002
6	Proteins (Proteins, Gene)FDA Link 09/2020 - 10/2002
4	AngiotensinogenIBA 11/2018 - 04/2015
4	metal transporting protein 1 (ferroportin)IBA 06/2015 - 11/2010
3	AcidsIBA 07/2021 - 03/2016
3	DNA (Deoxyribonucleic Acid)IBA 09/2020 - 01/2018
3	Biomarkers (Surrogate Marker)IBA 04/2020 - 11/2010
3	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 09/2010
3	Fluorouracil (Carac)FDA LinkGeneric 02/2018 - 01/2016
3	Messenger RNA (mRNA)IBA 01/2017 - 07/2012
3	Matrix Metalloproteinases (MMPs)IBA 01/2011 - 09/2010
3	oxidized low density lipoproteinIBA 01/2011 - 09/2010
3	LDL CholesterolIBA 01/2011 - 09/2010
3	Cholesterol Esters (Cholesteryl Esters)IBA 01/2011 - 09/2010
3	CholesterolIBA 01/2011 - 09/2010
3	HDL CholesterolIBA 01/2011 - 09/2010
2	SteroidsIBA 10/2021 - 07/2002
2	Proton Pump InhibitorsIBA 07/2021 - 03/2016
2	MelatoninIBA 01/2019 - 12/2016
2	Insulin (Novolin)FDA Link 09/2018 - 01/2003
2	Angiotensin IIIBA 06/2018 - 05/2016
2	CytokinesIBA 01/2017 - 07/2014
2	Cytochrome P-450 CYP2C19IBA 03/2016 - 08/2014
2	CopperIBA 06/2015 - 10/2002
2	GABA-A Receptors (GABA(A) Receptor)IBA 12/2014 - 12/2013
2	AntibodiesIBA 12/2013 - 05/2002
2	HepcidinsIBA 11/2010 - 11/2010
2	Thiamine (Aneurin)FDA Link 11/2010 - 04/2009
2	Glucosylceramidase (Glucocerebrosidase)IBA 09/2010 - 01/2007
2	Immunoglobulin E (IgE)IBA 09/2003 - 05/2002
2	Free RadicalsIBA 03/2003 - 03/2002
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2022
1	Liposomes (Liposome)IBA 01/2022
1	Clodronic Acid (Clodronate)IBA 01/2022
1	Creatine Kinase (Creatine Phosphokinase)IBA 10/2021
1	1- (5- (2- fluorophenyl)- 1- (pyridin- 3- ylsulfonyl)- 1H- pyrrol- 3- yl)- N- methylmethanamineIBA 07/2021
1	Colchicine FDA LinkGeneric 01/2021
1	PlatinumIBA 11/2020
1	nedaplatinIBA 11/2020
1	Phosphotransferases (Kinase)IBA 09/2020
1	Leucine (L-Leucine)FDA Link 09/2020
1	MutS ProteinsIBA 09/2020
1	MutL Protein Homolog 1IBA 09/2020
1	SiliconesIBA 05/2020

Therapy/Procedure

10	Therapeutics 10/2021 - 07/2002
2	Chemoradiotherapy 11/2020 - 10/2018
2	Drug Therapy (Chemotherapy) 02/2018 - 12/2013
1	Nephrectomy 01/2022
1	Intravenous Administration 01/2022
1	Splenectomy 01/2022